Visitors can get down to business in Milan, Italy's economic and fashion center. Its shops feature some of the world's most magnificent clothes. Not far from world's top design houses lies the city's business and financial center. The Duomo, or cathedral, in Milan is not to be missed — it's one of the largest in the world. The late-Gothic style cathedral boasts marble pillars and a nail said to come from Christ's cross. (GUY VANDEREIST—GETTY IMAGES)